Sampling Bourbon, Spice Rum and Santa’s Little Helper Cream Liqueur. Twelve 33 Distillery is a small production, craft distillery located in Little River, South Carolina on Highway 90 and Highway 17, just north of North Myrtle Beach. The location is ideally located on the busiest highway leading into the “Grand Strand”, a premier tourist destination for its world class golf and white sand beaches. Each of our handcrafted spirits are made from grains and other ingredients sourced directly from local farms. This allows us to proudly create premium products entirely from South Carolina.